V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL) (Middle Region) Peptide
CRKL
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CrkL (CRKL) products
- CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RSSPHGKHGN RNSNSYGIPE PAHAYAQPQT TTPLPAVSGS PGAAITPLPS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CRKL Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL) peptide
CRKL Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))
- Synonyms
- CRKL Peptide, wu:fa55g05 Peptide, wu:fj60e01 Peptide, zgc:63469 Peptide, 1110025F07Rik Peptide, AA589403 Peptide, AI325100 Peptide, Crkol Peptide, CRK like proto-oncogene, adaptor protein Peptide, v-crk avian sarcoma virus CT10 oncogene homolog-like Peptide, CRKL Peptide, crkl Peptide, Crkl Peptide
- Background
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CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.
Alias Symbols: -
Protein Size: 303 - Molecular Weight
- 34 kDa
- Gene ID
- 1399
- NCBI Accession
- NM_005207, NP_005198
- UniProt
- P46109
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