Crystallin, alpha B (CRYAB) Peptide
CRYAB
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN975336
Quick Overview for Crystallin, alpha B (CRYAB) Peptide (ABIN975336)
Target
CRYAB
(Crystallin, alpha B (CRYAB))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-CRYAB antibody (Catalog #: ARP48196_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Crystallin, alpha B (CRYAB) peptide
CRYAB Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CRYAB (Crystallin, alpha B (CRYAB))
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Background
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Alpha crystallins are composed of: alpha-A and alpha-B, for acidic and basic, respectively. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy.
Alias Symbols: CRYA2, CTPP2, HSPB5
Protein Interaction Partner: BAX,BCL2L1,APP,BCL2L1,BMPR2,CRYAA,CRYAB,CRYBB2,CRYGC,CS,EPB41,HSPB1,PSMA3,TTN,BMPR2,CRYAA,CRYAB,CRYBB2,CRYGC,CS,HSPB1,HSPB2,PSMA3
Protein Size: 108 -
Molecular Weight
- 12 kDa
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Gene ID
- 1410
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NCBI Accession
- NM_001885
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UniProt
- P02511
Target
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