E2F Transcription Factor 6 (E2F6) Peptide
E2F6
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all E2F6 products
- E2F6 (E2F Transcription Factor 6 (E2F6))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-E2F6 antibody (Catalog #: ARP32221_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- E2F6 (E2F Transcription Factor 6 (E2F6))
- Synonyms
- E2F-6 Peptide, AI462434 Peptide, E2F6b Peptide, EMA Peptide, E2F transcription factor 6 Peptide, E2F6 Peptide, E2f6 Peptide
- Background
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E2F6 is a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants encoding several different isoforms have been found for this gene.
Alias Symbols: E2F-6
Protein Interaction Partner: BMI1,E2F1,EPC1,EZH2,PCGF6,RING1,RYBP,TFDP1,TFDP2,BMI1,CBX3,E2F6,EZH1,EZH2,KDM5C,PCGF6,RING1,RYBP,TFDP1,TFDP2,ZMYND11,ZMYND8
Protein Size: 129 - Molecular Weight
- 14 kDa
- Gene ID
- 1876
- NCBI Accession
- NM_212540, NP_997705
- UniProt
- Q6Q9Z5
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