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Vacuolar-sorting Protein SNF8 (SNF8) Peptide

SNF8 Reactivity: Human Host: Synthetic BP, WB, IHC
Catalog No. ABIN976089
  • Target See all SNF8 products
    SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))
    Origin
    Human
    Source
    • 5
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-SNF8 antibody (Catalog #: ARP31531_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))
    Background
    ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL, MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741], Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM].

    Alias Symbols: Dot3, EAP30, VPS22

    Protein Interaction Partner: CHMP6,DVL2,ELL,NIF3L1,TSG101,VPS25,VPS36,DVL2,ELL,NIF3L1,VPS25

    Protein Size: 258
    Molecular Weight
    29 kDa
    Gene ID
    11267
    NCBI Accession
    NM_007241, NP_009172
    UniProt
    Q96H20
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