Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) Peptide
ERCC8
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN976414
Quick Overview for Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) Peptide (ABIN976414)
Target
ERCC8
(Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ERCC8 antibody (Catalog #: ARP32149_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
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Background
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ERCC8 is a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.
Alias Symbols: CKN1, CSA
Protein Interaction Partner: CBR1,DDB1,ERCC6,GTF2H2,UQCRQ,XAB2,COPS5,COPS6,CUL4A,CUL4B,DDB1,XAB2
Protein Size: 396 -
Molecular Weight
- 44 kDa
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Gene ID
- 1161
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NCBI Accession
- NM_000082, NP_000073
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UniProt
- Q13216
Target
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