Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8) (C-Term) Peptide
ERCC8
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ERCC8 products
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- TVGTDNRMRL WNSSNGENTL VNYGKVCNNS KKGLKFTVSC GCSSEFVFVP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ERCC8 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ERCC8 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 8 (ERCC8))
- Synonyms
- zgc:103550 Peptide, CKN1 Peptide, CSA Peptide, UVSS2 Peptide, Ckn1 Peptide, 2410022P04Rik Peptide, 2810431L23Rik Peptide, 4631412O06Rik Peptide, B130065P18Rik Peptide, Csa Peptide, excision repair cross-complementation group 8 Peptide, ERCC excision repair 8, CSA ubiquitin ligase complex subunit Peptide, excision repaiross-complementing rodent repair deficiency, complementation group 8 Peptide, ercc8 Peptide, ERCC8 Peptide, Ercc8 Peptide
- Background
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ERCC8 is a substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner, ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription- coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.
Alias Symbols: ERCC8,CKN1, CSA,
Protein Size: 396 - Gene ID
- 1161
- UniProt
- Q13216
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