F-Box and WD Repeat Domain Containing 7 (FBXW7) (Middle Region) Peptide
FBXW7
Reactivity: Mouse
Host: Synthetic
BP, WB, IHC
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- Target See all FBXW7 products
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Protein Region
- Middle Region
- Origin
- Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- GIDEPLHIKR RKIIKPGFIH SPWKSAYIRQ HRIDTNWRRG ELKSPKVLKG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Fbxw7 Antibody(ARP37443_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Synonyms
- cdc4 Peptide, AGO Peptide, CDC4 Peptide, FBW6 Peptide, FBW7 Peptide, FBX30 Peptide, FBXO30 Peptide, FBXW6 Peptide, SEL-10 Peptide, SEL10 Peptide, hAgo Peptide, hCdc4 Peptide, 1110001A17Rik Peptide, Cdc4 Peptide, Fbw7 Peptide, Fbwd6 Peptide, Fbx30 Peptide, Fbxo30 Peptide, Fbxw6 Peptide, F-box and WD repeat domain containing 7 Peptide, F-box and WD-40 domain protein 7 Peptide, Fbxw7 Peptide, FBXW7 Peptide, fbxw7 Peptide
- Background
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Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Alias Symbols: 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
Protein Interaction Partner: Jun,Npm1
Protein Size: 629 - Molecular Weight
- 70 kDa
- Gene ID
- 50754
- NCBI Accession
- NM_080428, NP_536353
- UniProt
- Q8VBV4
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