FK506 Binding Protein 1A, 12kDa (FKBP1A) (N-Term) Peptide
FKBP1A
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN976869
$160.46
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100 μg
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Quick Overview for FK506 Binding Protein 1A, 12kDa (FKBP1A) (N-Term) Peptide (ABIN976869)
Target
FKBP1A
(FK506 Binding Protein 1A, 12kDa (FKBP1A))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- GQTCVVHYTG MLEDGKKFDS SRDRNKPFKF MLGKQEVIRG WEEGVAQMSV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FKBP1A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))
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Background
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The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.
Alias Symbols: FKBP-12, FKBP1, FKBP12, FKBP12C, PKC12, PKCI2, PPIASE, FKBP-1A
Protein Interaction Partner: MTOR,TGFBR1,DHFR,FKBP1A,FKBP4,GLMN,ITPR1,MTOR,PPP3CA,PPP3R1,RYR1,RYR3,TGFB1I1,TGFBR1,TRPC3,YY1,ACVR1B,BMPR1A,DHFR,FKBP1A,GLMN,ITPR1,MTOR,Mtor,Mtor,RPTOR,RYR1,RYR3,SMAD7,TGFB1,TGFBR1,YY1
Protein Size: 108 -
Molecular Weight
- 12 kDa
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Gene ID
- 2280
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NCBI Accession
- NM_000801, NP_000792
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UniProt
- P62942
Target
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