Fibroblast Growth Factor Receptor Substrate 3 (FRS3) (Middle Region) Peptide
FRS3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977103
Quick Overview for Fibroblast Growth Factor Receptor Substrate 3 (FRS3) (Middle Region) Peptide (ABIN977103)
Target
FRS3
(Fibroblast Growth Factor Receptor Substrate 3 (FRS3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-FRS3 antibody (Catalog #: ARP52228_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FRS3 (Fibroblast Growth Factor Receptor Substrate 3 (FRS3))
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Background
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FRS3 is an adapter protein that links FGR and NGF receptors to downstream signaling pathways. FRS3 is involved in the activation of MAP kinases. FRS3 down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FRS2B, FRS2beta, MGC17167, SNT-2, SNT2
Protein Interaction Partner: FGFR1,NTRK1,PRKCI,BMPR2,FGFR1,GRB2,KARS,MAPK1,NTRK1,NTRK2,PRKCI,PTPN11,RND1,BMPR2,FGFR1
Protein Size: 492 -
Molecular Weight
- 54 kDa
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Gene ID
- 10817
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NCBI Accession
- NM_006653, NP_006644
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UniProt
- O43559
Target
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