Glutamate Receptor, Metabotropic 7 (GRM7) (C-Term) Peptide
GRM7
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977702
$160.46
Plus shipping costs $50.00
100 μg
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United States
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Quick Overview for Glutamate Receptor, Metabotropic 7 (GRM7) (C-Term) Peptide (ABIN977702)
Target
GRM7
(Glutamate Receptor, Metabotropic 7 (GRM7))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-GRM7 Antibody(ARP59604_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Glutamate Receptor, Metabotropic 7 (GRM7) peptide
GRM7 Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
Glutamate Receptor, Metabotropic 7 (GRM7) peptideGRM7 Host: Synthetic BP, WB, IHC
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))
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Background
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L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: FLJ40498, GLUR7, GPRC1G, MGLU7, MGLUR7
Protein Interaction Partner: GRIP1,PICK1,SDCBP,CALM1,CALM3,CALM3,FLNA,GNAQ,GRIPAP1,PICK1,TUBA1A,TUBA1B,TUBA3C,TUBA4A,TUBA8,GNAQ,PICK1,PRKCA
Protein Size: 915 -
Molecular Weight
- 99 kDa
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Gene ID
- 2917
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NCBI Accession
- NM_000844, NP_000835
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UniProt
- Q14831
Target
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