Hect Domain and RLD 5 (HERC5) (N-Term) Peptide
HERC5
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN977936
Quick Overview for Hect Domain and RLD 5 (HERC5) (N-Term) Peptide (ABIN977936)
Target
HERC5
(Hect Domain and RLD 5 (HERC5))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HERC5 antibody (Catalog #: ARP43212_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HERC5 (Hect Domain and RLD 5 (HERC5))
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Background
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HERC5 is a probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
Alias Symbols: CEB1, CEBP1
Protein Interaction Partner: CCNA2,CCNB1,CCND1,CCNE1,CCNA2,CCNB1,CCND1,CCNE1,CDKN1A,ERCC2,NME2,PITX2,STK38
Protein Size: 1024 -
Molecular Weight
- 117 kDa
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Gene ID
- 51191
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NCBI Accession
- NM_016323, NP_057407
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UniProt
- Q9UII4
Target
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