Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1) (N-Term) Peptide
HSD11B1
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all HSD11B1 products
- HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HSD11B1 antibody (Catalog #: ARP45714_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HSD11B1 (Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1))
- Synonyms
- 11-DH Peptide, 11-beta-HSD1 Peptide, CORTRD2 Peptide, HDL Peptide, HSD11 Peptide, HSD11B Peptide, HSD11L Peptide, SDR26C1 Peptide, hsd11 Peptide, hsd11b Peptide, LRRGT00065 Peptide, hydroxysteroid 11-beta dehydrogenase 1 Peptide, hydroxysteroid (11-beta) dehydrogenase 1b Peptide, hydroxysteroid (11-beta) dehydrogenase 1 L homeolog Peptide, HSD11B1 Peptide, HSD11B1b Peptide, hsd11b1.L Peptide, Hsd11b1 Peptide
- Background
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HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: 11-DH, 11-beta-HSD1, HDL, HSD11, HSD11B, HSD11L, MGC13539, SDR26C1
Protein Interaction Partner: CD36
Protein Size: 292 - Molecular Weight
- 32 kDa
- Gene ID
- 3290
- NCBI Accession
- NM_005525, NP_005516
- UniProt
- P28845
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