Interleukin 1, beta (IL1B) Peptide
Quick Overview for Interleukin 1, beta (IL1B) Peptide (ABIN978486)
Target
Origin
Source
Application
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-IL1B antibody (Catalog #: ARP54324_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Interleukin 1, beta (IL1B) (AA 117-269) peptide
IL1B Reactivity: Human Host: Escherichia coli (E. coli) SDS
Interleukin 1, beta (IL1B) (AA 199-214) peptide (BSA)IL1B Reactivity: Rat Host: Synthetic WB, SDS, Imm
Interleukin 1, beta (IL1B) (AA 199-214) peptide (BSA)IL1B Reactivity: Mouse Host: Synthetic WB, SDS, Imm
Interleukin 1, beta (IL1B) (AA 199-214) peptide (Ovalbumin)IL1B Reactivity: Rat Host: Synthetic WB, SDS, Imm
Interleukin 1, beta (IL1B) (AA 199-214) peptide (Ovalbumin)IL1B Reactivity: Mouse Host: Synthetic WB, SDS, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))
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Background
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IL1B is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. The gene encoding IL1B and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IL-1, IL1-BETA, IL1F2
Protein Interaction Partner: A2M,ADRB2,CASP1,CASP4,IL1B,IL1R1,IL1R2,IL1RAP,MMP2,PRTN3,IL1R1,MAPK8IP2,UBE2N,ZNF675
Protein Size: 153 -
Molecular Weight
- 17 kDa
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Gene ID
- 3553
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NCBI Accession
- NM_000576, NP_000567
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UniProt
- P01584
Target
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