Interleukin 7 Receptor (IL7R) (Middle Region) Peptide
IL7R
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN978517
$160.46
Plus shipping costs $50.00
100 μg
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United States
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Quick Overview for Interleukin 7 Receptor (IL7R) (Middle Region) Peptide (ABIN978517)
Target
IL7R
(Interleukin 7 Receptor (IL7R))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- ESFLDCQIHR VDDIQARDEV EGFLQDTFPQ QLEESEKQRL GGDVQSPNCP
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-IL7R Antibody(ARP59084_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- IL7R (Interleukin 7 Receptor (IL7R))
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Background
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The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
Alias Symbols: CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Protein Interaction Partner: IL7,CRLF2,FYN,IL2RG,IL7,JAK1,JAK3,LYN,PIK3R1,PTK2B,STAT3,STAT5A,STAT5B,TSLP,FYN,PTK2B
Protein Size: 459 -
Molecular Weight
- 49 kDa
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Gene ID
- 3575
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NCBI Accession
- NM_002185, NP_002176
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UniProt
- P16871
Target
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