Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3) (C-Term) Peptide
MAPKAPK3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN979808
Quick Overview for Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3) (C-Term) Peptide (ABIN979808)
Target
MAPKAP Kinase 3 (MAPKAPK3)
(Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- PLHTARVLQE DKDHWDEVKE EMTSALATMR VDYDQVKIKD LKTSNNRLLN
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MAPKAPK3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MAPKAP Kinase 3 (MAPKAPK3) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 (MAPKAPK3))
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Background
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MAPKAPK3 is a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
Alias Symbols: 3PK, MAPKAP3, MK-3, MAPKAP-K3, MAPKAPK-3
Protein Interaction Partner: BMI1,CBX4,PHC2,EEF2,EEF2K,HSPB1,MAPK13,MAPK14,TCF3,MAPK14,TCF3,UBC
Protein Size: 382 -
Molecular Weight
- 43 kDa
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Gene ID
- 7867
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NCBI Accession
- NM_004635, NP_004626
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UniProt
- Q16644
Target
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