Methyl-CpG Binding Domain Protein 1 (MBD1) (C-Term) Peptide
MBD1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MBD1 products
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- EEDKEENKDD SASKLAPEEE AGGAGTPVIT EIFSLGGTRF RDTAVWLPRS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MBD1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
- Synonyms
- CXXC3 Peptide, PCM1 Peptide, RFT Peptide, Cxxc3 Peptide, CCDC11 Peptide, methyl-CpG binding domain protein 1 Peptide, MBD1 Peptide, Mbd1 Peptide
- Background
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The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions, several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides, transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Alias Symbols: CXXC3, PCM1, RFT
Protein Size: 629 - Molecular Weight
- 69 kDa
- Gene ID
- 4152
- NCBI Accession
- NM_001204138, NP_001191067
- UniProt
- Q9UIS9
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