Mortality Factor 4 Like 1 (MORF4L1) (Middle Region) Peptide
MORF4L1
Reactivity: Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN980189
Quick Overview for Mortality Factor 4 Like 1 (MORF4L1) (Middle Region) Peptide (ABIN980189)
Target
MORF4L1
(Mortality Factor 4 Like 1 (MORF4L1))
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- PEELKPWLVD DWDLITRQKQ LFYLPAKKNV DSILEDYANY KKSRGNTDNK
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Morf4l1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MORF4L1 (Mortality Factor 4 Like 1 (MORF4L1))
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Background
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Morf4l1 is a component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
Alias Symbols: KIAA4002, MGC102415, MGC103105, MGC118047, MORFRG15, MRG15, TEG-189, Tex189, mKIAA4002
Protein Interaction Partner: PFN2,SIN3A,TLE1
Protein Size: 362 -
Molecular Weight
- 41 kDa
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Gene ID
- 21761
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NCBI Accession
- NM_001039147, NP_001034236
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UniProt
- P60762
Target
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