NLR Family, Pyrin Domain Containing 3 (NLRP3) (N-Term) Peptide
NLRP3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NLRP3 products
- NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LGESVSLNKR YTRLRLIKEH RSQQEREQEL LAIGKTKTCE SPVSPIKMEL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NLRP3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))
- Synonyms
- CIAS1 Peptide, Nalp3 Peptide, avp Peptide, cias1 Peptide, nalp3 Peptide, pypaf1 Peptide, agtavprl Peptide, AGTAVPRL Peptide, AII Peptide, AVP Peptide, C1orf7 Peptide, CLR1.1 Peptide, FCAS Peptide, FCU Peptide, MWS Peptide, NALP3 Peptide, PYPAF1 Peptide, AII/AVP Peptide, Cias1 Peptide, Mmig1 Peptide, Pypaf1 Peptide, NLR family pyrin domain containing-like Peptide, NLR family pyrin domain containing 3 Peptide, NLR family, pyrin domain containing 3 L homeolog Peptide, NLR family, pyrin domain containing 3 Peptide, NLRPL Peptide, NLRP3 Peptide, nlrp3.L Peptide, Nlrp3 Peptide
- Background
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This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID).
Alias Symbols: AGTAVPRL, AII, AII/AVP, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, FLJ95925, MWS, NALP3, PYPAF1
Protein Interaction Partner: PYCARD,CARD8,PYCARD,NLRC4,NLRC4
Protein Size: 1036 - Molecular Weight
- 114 kDa
- Gene ID
- 114548
- NCBI Accession
- NM_004895, NP_004886
- UniProt
- Q96P20
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