Notch 2 (NOTCH2) (Middle Region) Peptide
NOTCH2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NOTCH2 products
- NOTCH2 (Notch 2 (NOTCH2))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NOTCH2 antibody (Catalog #: ARP32723_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NOTCH2 (Notch 2 (NOTCH2))
- Synonyms
- AGS2 Peptide, HJCYS Peptide, hN2 Peptide, AI853703 Peptide, N2 Peptide, notch6 Peptide, sb:cb884 Peptide, neurogenic locus notch homolog protein 2 Peptide, notch 2 Peptide, notch 3 Peptide, LOC581186 Peptide, NOTCH2 Peptide, notch3 Peptide, Notch2 Peptide, notch2 Peptide
- Background
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NOTCH2 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. NOTCH2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH2 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: AGS2, hN2, HJCYS
Protein Interaction Partner: tat,CNTN1,DLL1,DTX1,GSK3B,JAG1,JAG2,LFNG,MAML1,MAML2,MAML3,MFNG,MYOC,PSEN1,PSEN2,RBPJ,SMAD1,CNTN1,DLL1,GSK3B,JAG1,JAG2,MAML1,RBPJ
Protein Size: 2471 - Molecular Weight
- 85 kDa
- Gene ID
- 4853
- NCBI Accession
- NM_024408, NP_077719
- UniProt
- Q04721
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