Notch 4 (NOTCH4) (C-Term) Peptide
NOTCH4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NOTCH4 products
- NOTCH4 (Notch 4 (NOTCH4))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- CDWVALGACG SASNIPIPPP CLTPSPERGS PQLDCGPPAL QEMPINQGGE
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NOTCH4 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NOTCH4 (Notch 4 (NOTCH4))
- Synonyms
- INT3 Peptide, NOTCH3 Peptide, Int-3 Peptide, Int3 Peptide, N4 Peptide, Notch4 Peptide, notch 4 Peptide, neurogenic locus notch homolog protein 4 Peptide, NOTCH4 Peptide, Notch4 Peptide, LOC100712850 Peptide
- Background
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NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. NOTCH4 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. NOTCH4 functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. NOTCH4 gene may be associated with susceptibility to schizophrenia in a small portion of cases.
Alias Symbols: FLJ16302, INT3, MGC74442, NOTCH3
Protein Interaction Partner: DLL4,FBXW7,MAML1,MAML2,MAML3,NOTCH4,PSEN1,PSEN2,RBPJ,SMAD2,SMAD3,SMAD4,MAML1
Protein Size: 2003 - Molecular Weight
- 58 kDa
- Gene ID
- 4855
- NCBI Accession
- NM_004557, NP_004548
- UniProt
- Q99466
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