NADPH Oxidase 1 (NOX1) Peptide
NOX1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NOX1 products
- NOX1 (NADPH Oxidase 1 (NOX1))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NOX1 antibody (Catalog #: ARP46818_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NOX1 (NADPH Oxidase 1 (NOX1))
- Synonyms
- GP91-2 Peptide, MOX1 Peptide, NOH-1 Peptide, NOH1 Peptide, NOX1a Peptide, NOX1alpha Peptide, Nox-1 Peptide, Nox1 Peptide, NADPH oxidase 1 Peptide, NOX1 Peptide, Nox1 Peptide, nox1 Peptide
- Background
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Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox.Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. They are unique among ion channels with respect to their extremely high selectivity, marked temperature dependence, and unitary conductance, which is 3 orders of magnitude lower than that of most other ion channels. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. The NOH-1S currents were reversibly blocked by zinc, a known H+ channel inhibitor. The NOH-1S variant does not contain an electron transport chain and it is thought that H+ conductance is its main physiologic function, whereas NOH-1L may conduct H+ ions as part of its electron transport mechanism.
Alias Symbols: GP91-2, MOX1, NOH-1, NOH1
Protein Interaction Partner: CYBA,CYBA
Protein Size: 564 - Molecular Weight
- 65 kDa
- Gene ID
- 27035
- NCBI Accession
- NM_007052, NP_008983
- UniProt
- Q9Y5S8
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