Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Neuregulin 1 (NRG1) Peptide

NRG1 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN980957
  • Target See all Neuregulin 1 (NRG1) products
    Neuregulin 1 (NRG1)
    Origin
    Human
    Source
    • 6
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-NRG1 antibody (Catalog #: ARP46954_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    Neuregulin 1 (NRG1)
    Synonyms
    6030402G23Rik Peptide, ARIA Peptide, D230005F13Rik Peptide, GGF Peptide, GGFII Peptide, HRG Peptide, HRGalpha Peptide, Hgl Peptide, NDF Peptide, SMDF Peptide, GGF2 Peptide, HGL Peptide, HRG1 Peptide, HRGA Peptide, MST131 Peptide, NRG-1 Peptide, heregulin Peptide, nrg1-A Peptide, pro-neuregulin-1 Peptide, NRG1 Peptide, wu:fm70e01 Peptide, DKFZp459A1838 Peptide, neuregulin 1 Peptide, histidine rich glycoprotein Peptide, neuregulin 1 L homeolog Peptide, Nrg1 Peptide, NRG1 Peptide, HRG Peptide, nrg1.L Peptide, nrg1 Peptide
    Background
    Neuregulin 1 (NRG1) interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains, and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.

    Alias Symbols: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, NDF, SMDF, MST131

    Protein Interaction Partner: ERBB3,ADAM19,EGF,ERBB3,ERBB4,IKZF4,LIMK1,DLG4,EGFR,ERBB2,ERBB3,ERBB4,IKZF4,LIMK1

    Protein Size: 637
    Molecular Weight
    70 kDa
    Gene ID
    3084
    NCBI Accession
    NM_013957, NP_039251
    UniProt
    Q7RTW3
You are here:
Support