2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) (Middle Region) Peptide
OAS1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN981070
Quick Overview for 2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) (Middle Region) Peptide (ABIN981070)
Target
OAS1
(2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
-
-
Protein Region
- Middle Region
-
Characteristics
- This is a synthetic peptide designed for use in combination with anti-OAS1 antibody (Catalog #: ARP51359_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
-
-
Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handling Advice
- Avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- OAS1 (2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1))
-
Background
-
This protein is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.
Alias Symbols: IFI-4, OIAS, OIASI
Protein Size: 414 -
Molecular Weight
- 47 kDa
-
Gene ID
- 4938
-
NCBI Accession
- NM_001032409, NP_001027581
Target
-
You are here:
