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Paired-Like Homeodomain 2 (PITX2) (N-Term) Peptide

PITX2 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN981800
  • Target See all PITX2 products
    PITX2 (Paired-Like Homeodomain 2 (PITX2))
    Protein Region
    N-Term
    Origin
    Human
    Source
    • 3
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    EHRAAGTKLS AVSSSSCHHP QPLAMASVLA PGQPRSLDSS KHRLEVHTIS
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-PITX2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    PITX2 (Paired-Like Homeodomain 2 (PITX2))
    Synonyms
    ARP1 Peptide, Brx1 Peptide, IDG2 Peptide, IGDS Peptide, IGDS2 Peptide, IHG2 Peptide, IRID2 Peptide, Otlx2 Peptide, PTX2 Peptide, RGS Peptide, RIEG Peptide, RIEG1 Peptide, RS Peptide, 9430085M16Rik Peptide, Brx1a Peptide, Brx1b Peptide, Munc30 Peptide, Pitx2a Peptide, Pitx2b Peptide, Pitx2c Peptide, Pitx2cbeta Peptide, Ptx2 Peptide, Rieg Peptide, pitx2a Peptide, pitx2c Peptide, zgc:110508 Peptide, XPtx2b Peptide, xPtx2 Peptide, xpitx2 Peptide, arp1 Peptide, brx1 Peptide, idg2 Peptide, igds Peptide, igds2 Peptide, ihg2 Peptide, irid2 Peptide, otlx2 Peptide, pitx2-A Peptide, ptx2 Peptide, rgs Peptide, rieg Peptide, rieg1 Peptide, pitx-2 Peptide, pitx2 Peptide, paired like homeodomain 2 Peptide, paired-like homeodomain transcription factor 2 Peptide, paired-like homeodomain 2 Peptide, paired like homeodomain 2 S homeolog Peptide, paired like homeodomain 2 L homeolog Peptide, PITX2 Peptide, Pitx2 Peptide, pitx2 Peptide, pitx2.S Peptide, pitx2.L Peptide
    Background
    This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.

    Alias Symbols: ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, PTX2, RGS, RIEG, RIEG1, RS

    Protein Interaction Partner: CTNNB1,HDAC1,KAT5,LEF1,PDLIM1,PITX2,PROP1,CTNNB1,HDAC1,HERC5,MSX2,PITX2,Pou1f1,SMAD3,TRIM25,ZNHIT3

    Protein Size: 324
    Molecular Weight
    36 kDa
    Gene ID
    5308
    NCBI Accession
    NM_000325, NP_000316
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