Regulator of Calcineurin 1 (RCAN1) (Middle Region) Peptide
RCAN1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982785
$160.46
Plus shipping costs $50.00
100 μg
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United States
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Quick Overview for Regulator of Calcineurin 1 (RCAN1) (Middle Region) Peptide (ABIN982785)
Target
RCAN1
(Regulator of Calcineurin 1 (RCAN1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-RCAN1 antibody (Catalog #: ARP38457_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RCAN1 (Regulator of Calcineurin 1 (RCAN1))
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Background
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RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease.The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
Alias Symbols: ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
Protein Interaction Partner: GSK3B,MAP3K3,MAPK3,PPP3CA,UXT,PPP3CA,UBC
Protein Size: 252 -
Molecular Weight
- 28 kDa
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Gene ID
- 1827
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NCBI Accession
- NM_004414, NP_004405
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UniProt
- P53805
Target
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