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RE1-Silencing Transcription Factor (REST) (Middle Region) Peptide

REST Reactivity: Mouse Host: Synthetic BP, WB

Catalog No. ABIN982857

Quick Overview for RE1-Silencing Transcription Factor (REST) (Middle Region) Peptide (ABIN982857)

Target

REST (RE1-Silencing Transcription Factor (REST))

Origin

Mouse

Source

Synthetic

Application

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

Middle Region

Sequence

ANMGMALTND MYDLHELSKA ELAAPQLIML ANVALTGEAS GSCCDYLVGE

Characteristics

This is a synthetic peptide designed for use in combination with anti-Rest Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Purification

Purified
RE1-Silencing Transcription Factor (REST) peptide
REST Host: Synthetic BP, Imm

RE1-Silencing Transcription Factor (REST) peptide
REST Reactivity: Mammalian Host: Synthetic BP, WB, IHC

RE1-Silencing Transcription Factor (REST) (N-Term) peptide
REST Reactivity: Human Host: Synthetic BP, WB

RE1-Silencing Transcription Factor (REST) (Middle Region) peptide
REST Reactivity: Human Host: Synthetic BP, WB

RE1-Silencing Transcription Factor (REST) peptide
REST Reactivity: Human, Mouse, Rat Host: Synthetic BP, WB, ICo, IDe

RE1-Silencing Transcription Factor (REST) peptide
REST Reactivity: Human Host: Synthetic BP, BI

Application Notes

Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Concentration

1 mg/mL

Buffer

Final peptide concentration is 1 mg/mL in PBS.

Handling Advice

Avoid repeated freeze-thaw cycles.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

REST (RE1-Silencing Transcription Factor (REST))

Background

Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

Alias Symbols: 2610008J04Rik, AA407358, MGC150099, NRSF

Protein Size: 1082

Molecular Weight

118 kDa

Gene ID

19712

NCBI Accession

NM_011263, NP_035393

UniProt

Q8VIG1

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