SIX Homeobox 1 (SIX1) (N-Term) Peptide
SIX1
Reactivity: Mouse
Host: Synthetic
BP, WB
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- Target See all SIX Homeobox 1 (SIX1) products
- SIX Homeobox 1 (SIX1)
- Protein Region
- N-Term
- Origin
- Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- ERLGRFLWSL PACDHLHKNE SVLKAKAVVA FHRGNFRELY KILESHQFSP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Six1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SIX Homeobox 1 (SIX1)
- Synonyms
- BOS3 Peptide, DFNA23 Peptide, TIP39 Peptide, BB138287 Peptide, six1b Peptide, six2 Peptide, zgc:92332 Peptide, XSix1 Peptide, six1 Peptide, zgc:77345 Peptide, SIX homeobox 1 Peptide, sine oculis-related homeobox 1 Peptide, SIX homeobox 1a Peptide, SIX homeobox 1 L homeolog Peptide, SIX homeobox 1b Peptide, SIX1 Peptide, Six1 Peptide, six1a Peptide, six1.L Peptide, six1b Peptide
- Background
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Six1 is a transcription factor that is involved in regulation of organogenesis. It seems to be required for development of kidney, muscle and inner ear and to be involved in later steps of myogenic differentiation. It may be involved in limb tendon and ligament development. It binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter. It is thought to be regulated by association with Dach and Eya proteins. Six1 acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 phosphatase to the SIX1-DACH1 complex. During myogenesis, Six1 seems to act together with EYA2 and DACH2 .
Alias Symbols: BB138287
Protein Size: 284 - Molecular Weight
- 32 kDa
- Gene ID
- 20471
- NCBI Accession
- NM_009189, NP_033215
- UniProt
- Q62231
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