Vacuolar-sorting Protein SNF8 (SNF8) (N-Term) Peptide
SNF8
Reactivity: Rat
Host: Synthetic
BP, WB
Catalog No. ABIN984183
Quick Overview for Vacuolar-sorting Protein SNF8 (SNF8) (N-Term) Peptide (ABIN984183)
Target
SNF8
(Vacuolar-sorting Protein SNF8 (SNF8))
Origin
Rat
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- GTVLAEDQLA QMSKQLDMFK TNLEEFASKH KQEIRKNPEF RVQFQDMCAT
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Snf8 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))
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Background
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Snf8 is required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is a component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL.
Alias Symbols: D11moh34, MGC105799, RGD1310144
Protein Size: 258 -
Molecular Weight
- 28 kDa
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Gene ID
- 287645
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NCBI Accession
- NM_001007804, NP_001007805
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UniProt
- Q5RK19
Target
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