Vacuolar-sorting Protein SNF8 (SNF8) Peptide
SNF8
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN984184
Quick Overview for Vacuolar-sorting Protein SNF8 (SNF8) Peptide (ABIN984184)
Target
SNF8
(Vacuolar-sorting Protein SNF8 (SNF8))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SNF8 antibody (Catalog #: ARP57949_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SNF8 (Vacuolar-sorting Protein SNF8 (SNF8))
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Background
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ELL encodes an RNA polymerase II transcription factor that undergoes frequent translocation in acute myeloid leukemia (AML). In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription. EAP30 is a subunit of the ELL complex. EAP30 can interact with ELL and derepress ELL's inhibitory activity in vitro.SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor. SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL, MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741], Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM].
Alias Symbols: Dot3, EAP30, VPS22
Protein Interaction Partner: CHMP6,DVL2,ELL,NIF3L1,TSG101,VPS25,VPS36,DVL2,ELL,NIF3L1,VPS25
Protein Size: 258 -
Molecular Weight
- 29 kDa
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Gene ID
- 11267
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NCBI Accession
- NM_007241, NP_009172
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UniProt
- Q96H20
Target
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