Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (N-Term) Peptide
STAT3
Reactivity: Human
Host: Synthetic
BP, WB, IF, IHC
Catalog No. ABIN984529
$160.46
Plus shipping costs $50.00
100 μg
Shipping to:
United States
Delivery in 11 to 17 Business Days
Quick Overview for Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) (N-Term) Peptide (ABIN984529)
Target
STAT3
(Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
-
-
Protein Region
- N-Term
-
Characteristics
- This is a synthetic peptide designed for use in combination with anti-STAT3 antibody (Catalog #: ARP38253_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) peptide
STAT3 Reactivity: Human, Mouse, Rat, Dog Host: Synthetic BP, Imm
-
-
Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handling Advice
- Avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3))
-
Background
-
STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. It mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein.The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Alias Symbols: APRF, FLJ20882, MGC16063, HIES
Protein Interaction Partner: NMI,BHLHE40,CREBBP,EGFR,EP300,HDAC1,HDAC2,HDAC3,NMI,PRKCB,PRKCD,STAT3,BHLHE40,AR,BHLHE40,BMX,BRCA1,CCND1,CCR1,CCR5,CDKN1A,CREBBP,CSF2RB,CSF3R,CXCR4,DAXX,EGFR,EIF2AK2,ELP2,EP300,EPHA3,FER,FES,FGFR3,FGFR4,FOXM1,GATA1,GATA2,GHR,GNB2L1,GTF2I,HCK,HDAC1,HDAC2,HDAC3,HES1,HES5,HIF1A,HNF1A,HSP90AA1,HSP90AB1,IFNAR1,IFNAR2,IGF1R,IL1RAP,IL23R,IL2RA,IL2RB,IL6R,IL6ST,IL7R,IRAK1,JAK1,JAK2,JAK3,JUN,KAT5,KHDRBS1,KPNA1,KPNA6,LCK,LEPR,MAP3K7,MAPK1,MAPK3,MAPK8,MET,MTOR,MYOD1,NCOA1,NDUFA13,NFKB1,NLK,NMI,NR3C1,PDGFRA,PDGFRB,PDIA3,PIAS3,PML,PRKCD,PTK2B,PTMA,PTPN11,PTPN2,RAC1,RELA,RET,RPA2,RPS6KA5,SRC,STAP2,STAT1,STAT3,STAT4,STAT5A,STAT5B,STMN1,SUMO4,SYK,TSHR,TSLP,ZNF148,ZNF467,A2M,ALK,AR,BMX,CCND1,CCND1,CCR5,CDKN1A,CREBBP,CTR9,EGFR,EIF2AK2,ELP2,EP300,EPHA5,ERBB2,ESR1,FES,FOS,GHR,GTF2I,HIF1A,HNF1A,HSP90AA1,IFNAR1,IL1RAP,IL2RB,IL6R,IL6ST,IL6ST,JAK1,JAK2,JUN,KAT5,KHDRBS1,LEP,MET,MTOR,MYOD1,NCOA1,NDUFA13,NDUFA13,NFKB1,NMI,NR3C1,PDIA3,PIAS3,PML,PTK2,PTPN11,PTPN2,RAC1,RELA,RET,RPA2,SMAD1,SRC,STAT1,TRIP10,TSHR
Protein Size: 769 -
Molecular Weight
- 88 kDa
-
Gene ID
- 6774
-
NCBI Accession
- NM_003150, NP_003141
-
UniProt
- B5BTZ6
Target
-
You are here:
