Transcription Factor B2, Mitochondrial (TFB2M) Peptide
TFB2M
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TFB2M products
- TFB2M (Transcription Factor B2, Mitochondrial (TFB2M))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TFB2M antibody (Catalog #: ARP39550_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Transcription Factor B2, Mitochondrial (TFB2M) peptide
TFB2M Reactivity: Human Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TFB2M (Transcription Factor B2, Mitochondrial (TFB2M))
- Synonyms
- CG3910 Peptide, Dmel\\CG3910 Peptide, TFB2 Peptide, d-TF2BM Peptide, d-mtTFB2 Peptide, TFB2M Peptide, sb:cb857 Peptide, hkp1 Peptide, Hkp1 Peptide, mtTFB2 Peptide, mitochondrial transcription factor B2 Peptide, transcription factor B2, mitochondrial Peptide, mtTFB2 Peptide, TFB2M Peptide, tfb2m Peptide, Tfb2m Peptide
- Background
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TFB2M is a S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. It is also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. It stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
Alias Symbols: FLJ22661, FLJ23182, Hkp1, mtTFB2
Protein Interaction Partner: PNP,POLRMT,TFAM,TFB2M,TFAM
Protein Size: 396 - Molecular Weight
- 45 kDa
- Gene ID
- 64216
- NCBI Accession
- NM_022366, NP_071761
- UniProt
- Q9H5Q4
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