Exoribonuclease 1 (ERI1) (N-Term) Peptide
ERI1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ERI1 products
- ERI1 (Exoribonuclease 1 (ERI1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SKFITSSASD FSDPVYKEIA ITNGCINRMS KEELRAKLSE FKLETRGVKD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- ERI1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ERI1 (Exoribonuclease 1 (ERI1))
- Synonyms
- THEX1 Peptide, thex1 Peptide, zgc:110635 Peptide, hexo Peptide, Eri-1 Peptide, 3'HEXO Peptide, HEXO Peptide, 3'hexo Peptide, 3110010F15Rik Peptide, Thex1 Peptide, eri-1 Peptide, RGD1308378 Peptide, exoribonuclease 1 Peptide, three prime repair exonuclease 1 Peptide, exoribonuclease 1 L homeolog Peptide, 3'-5' exonuclease eri-1 Peptide, ERI1 Peptide, CpipJ_CPIJ003945 Peptide, eri1 Peptide, eri1.L Peptide, Eri1 Peptide, eri-1 Peptide
- Background
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RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Alias Symbols: HEXO, THEX1, 3'HEXO
Protein Size: 349 - Molecular Weight
- 40 kDa
- Gene ID
- 90459
- NCBI Accession
- NM_153332, NP_699163
- UniProt
- Q8IV48
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