Tyrosine Kinase, Non-Receptor, 1 (TNK1) (C-Term) Peptide
TNK1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN985328
$160.46
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100 μg
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Quick Overview for Tyrosine Kinase, Non-Receptor, 1 (TNK1) (C-Term) Peptide (ABIN985328)
Target
TNK1
(Tyrosine Kinase, Non-Receptor, 1 (TNK1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- EIRQARAVPQ GPPGLPPRPP LSSSSPQPSQ PSRERLPWPK RKPPHNHPMG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TNK1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))
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Background
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The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: MGC46193
Protein Interaction Partner: PLCG1,PLCG1,SFN,TNK1,UBC
Protein Size: 661 -
Molecular Weight
- 72 kDa
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Gene ID
- 8711
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NCBI Accession
- NM_003985, NP_003976
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UniProt
- Q13470
Target
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