Tyrosine Kinase 2 (TYK2) (C-Term) Peptide
TYK2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TYK2 products
- TYK2 (Tyrosine Kinase 2 (TYK2))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TYK2 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TYK2 (Tyrosine Kinase 2 (TYK2))
- Synonyms
- JTK1 Peptide, tyrosine kinase 2 Peptide, TYK2 Peptide, Tyk2 Peptide
- Background
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This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Alias Symbols: JTK1
Protein Interaction Partner: GNB2L1,IFNAR2,IL12RB1,JAKMIP1,CBL,CRKL,EIF2AK2,FYN,GHR,GNB2L1,IFNAR2,IL13RA1,IL6ST,IRS1,IRS2,JAK1,JAKMIP1,LYN,PDGFRB,PIK3R1,PLAUR,PRMT5,PTAFR,PTPN1,PTPN6,PTPRC,STAM2,STAT1,STAT2,TYK2,VAV1,XRCC5,CBL,CRKL,ELP2,FYN,GHR,GNB2L1,IFNAR1,IL13RA1,IL6ST,IRS2,JAK1,L
Protein Size: 1187 - Molecular Weight
- 134 kDa
- Gene ID
- 7297
- NCBI Accession
- NM_003331, NP_003322
- UniProt
- P29597
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