Ubiquitin Protein Ligase E3A (ube3a) (N-Term) Peptide
ube3a
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ube3a products
- ube3a (Ubiquitin Protein Ligase E3A (ube3a))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-UBE3A antibody (Catalog #: ARP42950_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ube3a (Ubiquitin Protein Ligase E3A (ube3a))
- Synonyms
- ANCR Peptide, AS Peptide, E6-AP Peptide, EPVE6AP Peptide, HPVE6A Peptide, DDBDRAFT_0188760 Peptide, DDBDRAFT_0302447 Peptide, DDB_0188760 Peptide, DDB_0302447 Peptide, ube3a Peptide, im:7140733 Peptide, zgc:92173 Peptide, 4732496B02 Peptide, 5830462N02Rik Peptide, A130086L21Rik Peptide, Hpve6a Peptide, mKIAA4216 Peptide, As Peptide, CG6190 Peptide, Dmel\\CG6190 Peptide, Dube3a Peptide, UBE3A Peptide, dUBE3A Peptide, das Peptide, dube3A Peptide, dube3a Peptide, MGC69536 Peptide, UME3A Peptide, ubiquitin protein ligase E3A Peptide, ubiquitin-protein ligase E3A Peptide, Ubiquitin protein ligase E3A Peptide, ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) S homeolog Peptide, ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) Peptide, UBE3A Peptide, ube3a Peptide, LOC100194730 Peptide, Ube3a Peptide, ube3a.S Peptide, Eint_040430 Peptide
- Background
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UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Alias Symbols: ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A
Protein Interaction Partner: UBE2L3,UBE2L6,AR,BLK,BPY2B,BPY2C,BPY2C,EAPP,MCM7,PGR,PHF17,RARA,SCAMP1,SHBG,SMAD9,TP53,UBE2D1,UBE2D3,UBE2E1,UBE2G1,UBE2G2,UBE2L3,UBE2L6,UBE3A,UBQLN2,BARD1,BLK,BPY2,BRCA1,ESR2,LCK,MCM7,PGR,TSC2,UBE2D1,UBE2D2,UBE2D3,UBE2L3,UBQLN1,UBQLN2
Protein Size: 875 - Molecular Weight
- 101 kDa
- Gene ID
- 7337
- NCBI Accession
- NM_000462, NP_000453
- UniProt
- Q05086
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