Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (N-Term) Peptide
UBR1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN985867
$160.46
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100 μg
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Quick Overview for Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1) (N-Term) Peptide (ABIN985867)
Target
UBR1
(Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-UBR1 antibody (Catalog #: ARP43459_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1 (UBR1))
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Background
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UBR1 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. UBR1 may be involved in pancreatic homeostasis.The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: JBS, MGC142065, MGC142067
Protein Interaction Partner: ANXA3,ARL15,ARL3,ARL4D,BTBD2,CDC42,DNAJB11,FTH1,LAMA4,NDUFA4L2,PTPRS,SERPINB9,TAC3,TP53I3,UBE2B,ANXA3,ARL15,ARL3,ARL4D,BTBD2,CDC42,DLEU1,DNAJB11,FTH1,HNRNPA1,LAMA4,NDUFA4L2,PTPRS,SERPINB9,TAC3,TP53I3,UBE2B
Protein Size: 1749 -
Molecular Weight
- 200 kDa
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Gene ID
- 197131
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NCBI Accession
- NM_174916, NP_777576
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UniProt
- Q8IWV7
Target
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