Zinc Finger Protein 265 (Zranb2) Peptide
Zranb2
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ZNF265 (Zranb2) products
- ZNF265 (Zranb2) (Zinc Finger Protein 265 (Zranb2))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ZNF265 antibody (Catalog #: ARP37747_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ZNF265 (Zranb2) (Zinc Finger Protein 265 (Zranb2))
- Synonyms
- ZNF265 Peptide, ZRANB2 Peptide, c4sr Peptide, zis Peptide, zis1 Peptide, zis2 Peptide, znf265 Peptide, zranb2 Peptide, ZIS Peptide, ZIS1 Peptide, ZIS2 Peptide, AI227013 Peptide, Zfp265 Peptide, Zis Peptide, Znf265 Peptide, zinc finger RANBP2-type containing 2 Peptide, zinc finger RANBP2-type containing 2 L homeolog Peptide, zinc finger, RAN-binding domain containing 2 Peptide, ZRANB2 Peptide, zranb2.L Peptide, Zranb2 Peptide
- Background
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ZNF265 is a protein that has been shown to bind to the spliceosomal components U1-70K and U2AF35 and to direct alternative splicing. Analysis of the structure reveals substantial similarity to known RNA-binding motifs in terms of the distribution of key surface residues responsible for making RNA contacts, despite a complete lack of structural homology. An RNA gel shift assay was used to demonstrate that a single crossed finger domain from ZNF265 is capable of binding to an RNA message. Taken together, these results define a new RNA-binding motif and should provide insight into the functions of the >100 uncharacterized proteins in the sequence data bases that contain this domain.
Alias Symbols: ZIS, ZIS1, ZIS2, ZNF265
Protein Interaction Partner: EP300,SFRS12,SFRS17A,SMN2,SNRNP70,SRSF2,U2AF1,YY1,ZRANB2,ARRB1,SNRNP70,TRA2B,U2AF1,USP39
Protein Size: 330 - Molecular Weight
- 37 kDa
- Gene ID
- 9406
- NCBI Accession
- NM_203350, NP_976225
- UniProt
- Q5VV34
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