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Human Monoclonal HIP1 Primary Antibody for ChIP, ICC - ABIN152544
Rao, Hyun, Kumar, Mizukami, Rubin, Lucas, Sanda, Ross: Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. in The Journal of clinical investigation 2002
Show all 9 Pubmed References
Bacteria Monoclonal HIP1 Primary Antibody for ICC, IF - ABIN152545
Rao, Chang, Kumar, Mizukami, Smithson, Bradley, Parlow, Ross: Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. in Molecular and cellular biology 2001
Show all 7 Pubmed References
Human Monoclonal HIP1 Primary Antibody for IHC (p), IP - ABIN561263
Hibbert, Pflanz, De Waal Malefyt, Kastelein: IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2003
Show all 7 Pubmed References
Human Polyclonal HIP1 Primary Antibody for ELISA, WB - ABIN561262
Hwang, Hong, Glimcher: IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. in The Journal of experimental medicine 2005
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Monoclonal HIP1 Primary Antibody for WB - ABIN534063
Mills, Gaughan, Robson, Ross, McCracken, Kelly, Neal: Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. in The Journal of cell biology 2005
Show all 4 Pubmed References
Human Polyclonal HIP1 Primary Antibody for ICC, IF - ABIN4317501
Majeed, Vasudevan, Chen, Luo, Torres, Evans, Sharkey, Foraker, Wong, Esk, Freeman, Moffett, Keen, Brodsky: Clathrin light chains are required for the gyrating-clathrin recycling pathway and thereby promote cell migration. in Nature communications 2014
Huntingtin-interacting protein 1 (Hip1) functions in Notch (show NOTCH1 Antibodies)-mediated neurogenesis and provides a functional link between Notch (show NOTCH1 Antibodies) signaling and proteins related to Huntington disease (show HTT Antibodies).
Data suggest that GLP1R (show GLP1R Antibodies) signaling in pancreatic beta-cells leading to insulin (show INS Antibodies) secretion involves interactions of GLP1R (show GLP1R Antibodies) with HIP1, SNX1 (show SNX1 Antibodies), and SNX27 (show SNX27 Antibodies); HIP1 appears to regulate coupling of cell surface GLP1R (show GLP1R Antibodies) activation with endocytosis; SNX1 (show SNX1 Antibodies) and SNX27 (show SNX27 Antibodies) appear to control balance between GLP1R (show GLP1R Antibodies) plasma membrane recycling and lysosomal degradation.
HIP1 deletion is not involved in Williams-Beuren syndrome.
Huntingtin-interacting protein-1 (HIP1) is known to play a role in tumorigenesis. metastasis. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201412-2226OC#.V8DF69LrtNs
SHON is a novel human oncogene (show RAB1A Antibodies) with predictive utility in ER(+) breast cancer, perhaps offering a simple biomarker to predict the therapeutic efficacy of antiestrogen therapy in patients with breast cancer.
SHON plays an important role in EMT (show ITK Antibodies) and contributes to breast cancer progression.
HIP1-ALK, a novel fusion protein is associated with lung adenocarcinoma.
HIP1-ALK-rearranged tumor is sensitive to treatment with crizotinib, implicating HIP1-ALKas an oncogenic driver of lung tumorigenesis
Identified a four-tyrosine "HIP1 phosphorylation motif" in (show EGFR Antibodies) the N-terminal region of HIP1 that is required for phosphorylation mediated by both EGFR and PDGFbetaR but not by the oncoproteins HIP1/PDGFbetaR (H/P), and TEL/PDGFbetaR (T/P).
Three neuronal proteins (Huntingtin interacting protein 1, neurofascin (show NFASC Antibodies), and olfactomedin-like 2a) are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent (show SFRP5 Antibodies) formation.
flexibility of the HIP1 coiled-coil domain is important for normal function and may lead to new insights into Huntington's disease
we show that M. tuberculosis impairs dendritic cell cytokine secretion, maturation, and antigen presentation through the cell envelope-associated serine hydrolase (show SERHL Antibodies), Hip1.
HIP1 association with and phosphorylation mediated by EGFR (show EGFR Antibodies) and EGFRvIII.
Huntingtin-interacting protein 1 is a Merkel cell carcinoma marker that interacts with c-Kit (show KIT Antibodies)
Results show that pro-apoptotic Hippi (show IFT57 Antibodies)-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi (show IFT57 Antibodies), Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathw
HIP1 is the first endocytic protein to be directly implicated in tumor formation
disuprtion results in neurological deficits and decreased AMPA (show GRIA3 Antibodies) receptor trafficking
mice deficient in both HIP1 and HIP1r (show HIP1R Antibodies) have accelerated development of abnormalities seen in Hip1 -deficient mice, including kypholordosis and growth defects
The various abnormalities corroborate reduced fertility levels in HIP1(-/-) mice and suggest a role for HIP1 in stabilizing actin and microtubules, enabling normal spermatid and Sertoli cell morphology and function.
we have shown that HIP1 influences important NMDAR (show GRIN1 Antibodies) functions and that both HIP1 and htt (show HTT Antibodies) participate in NMDA-induced cell death.
Degenerative phenotypes seen in knockout mice are due mainly to HIP1 and HIP1r (show HIP1R Antibodies) protein deficiency rather than altered expression of neighboring genes or disrupted intronic elements.
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene.
, huntingtin interacting protein 1
, huntingtin-interacting protein 1
, huntingtin-interacting protein I