Browse our anti-NLRP12 (NLRP12) Antibodies

Human NLR Family, Pyrin Domain Containing 12 (NLRP12) interaction partners

1. report the crystal structure of NLRP12 PYD domain at 1.70 A fused with an maltose-binding protein (MBP (show MBL2 Antibodies)) tag

2. all of the reported mutations were found to have occurred in a highly conserved region in the NACHT domain coding sequence in NLRP12 exon 3, suggesting that a screening strategy for Familial cold autoinflammatory syndrome should focus on this area of the gene

3. The novel findings reveal the critical role of NLRP12-IL-17A (show IL17A Antibodies)-CXCL1 (show CXCL1 Antibodies) axis in host defense by modulating neutrophil recruitment against Klebsiella pneumoniae.

4. This process involved the upregulation of NLRP12.

5. NLRX1 (show NLRX1 Antibodies), NLRP12 and NLRC3 (show NLRC3 Antibodies) negatively modulate the host immune response following virus exposure. (Review)

6. Variants of NLRP12 were associated with common variable immunodeficiency.

7. NLRP12/NLRP3 (show NLRP3 Antibodies)-dependent activation of caspase-1 (show CASP1 Antibodies) is likely to be a key event in mediating systemic production of IL-1beta (show IL1B Antibodies) and hypersensitivity to secondary bacterial infection during malaria.

8. The genetics, expression and roles of NLRP12 in inflammatory signaling, host defense, and carcinogenes (show GUSB Antibodies)is are reviewed. Review.

9. This study suggested that NLRP12 mutations might account for a small fraction of common variable immunodeficiency patients with severe auto-inflammatory complications.

10. We will focus on NLRP6 (show NLRP6 Antibodies) and NLRP12.

Mouse (Murine) NLR Family, Pyrin Domain Containing 12 (NLRP12) interaction partners

1. Data show that TLR4 (show TLR4 Antibodies)-mediated up-regulation of Blimp-1 (show PRDM1 Antibodies) led to the down-regulation of NLRP12 expression in dextran sulfate sodium (DSS (show PMP22 Antibodies))-induced colitis.

2. this study shows that NLRP12 is essential for survival after radiation and thermal combined injury by regulating myelopoiesis and immune reconstitution

3. our findings suggest that NLRP12 plays an important role in negatively regulating the early inflammatory responses against B. abortus.

4. this study reveals a feed-forward loop in which NLRP12 promotes specific commensals that can reverse gut (show GUSB Antibodies) inflammation, while cytokine blockade during NLRP12 deficiency can reverse dysbiosis

5. Ambient fine particulate matter-induced myocarditis is mediated by EGFR (show EGFR Antibodies)/Akt (show AKT1 Antibodies) signaling and overexpression of NLRP3 (show NLRP3 Antibodies) and NLRP12.

6. The novel findings reveal the critical role of NLRP12-IL-17A (show IL17A Antibodies)-CXCL1 (show CXCL1 Antibodies) axis in host defense by modulating neutrophil recruitment against Klebsiella pneumoniae.

7. Nlrp12 deficiency caused increased neutrophil migration towards the chemokine (show CCL1 Antibodies) CXCL1 (show CXCL1 Antibodies) and the neutrophil parasite Leishmania major, revealing NLRP12 as a negative regulator of directed neutrophil migration under these conditions.

8. modulation of NLRP12 levels controls alternative NF-kappaB (show NFKB1 Antibodies) signaling in OC precursors, altering bone homeostasis and osteolytic responses

9. The absence of Nlrp12 results in an increased inflammatory response

10. NLRP12 is an intrinsic negative regulator of T-cell-mediated immunity via altered NF-kappaB (show NFKB1 Antibodies) regulation and IL-4 (show IL4 Antibodies) production as key mediators of NLRP12-associated disease.