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anti-Rat (Rattus) NLRP12 Antibodies:
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Human Polyclonal NLRP12 Primary Antibody for IHC (p), WB - ABIN657935
Cai, Batra, Del Piero, Jeyaseelan: NLRP12 modulates host defense through IL-17A-CXCL1 axis. in Mucosal immunology 2015
Patients with NLRP12 germline mutations and diagnosis of NLRP12-related autoinflammatory disease demonstrated highly variable clinical phenotypes.
report the crystal structure of NLRP12 PYD domain at 1.70 A fused with an maltose-binding protein (MBP (show MBL2 Antibodies)) tag
all of the reported mutations were found to have occurred in a highly conserved region in the NACHT domain coding sequence in NLRP12 exon 3, suggesting that a screening strategy for Familial cold autoinflammatory syndrome should focus on this area of the gene
The novel findings reveal the critical role of NLRP12-IL-17A (show IL17A Antibodies)-CXCL1 (show CXCL1 Antibodies) axis in host defense by modulating neutrophil recruitment against Klebsiella pneumoniae.
This process involved the upregulation of NLRP12.
NLRX1 (show NLRX1 Antibodies), NLRP12 and NLRC3 (show NLRC3 Antibodies) negatively modulate the host immune response following virus exposure. (Review)
Variants of NLRP12 were associated with common variable immunodeficiency.
NLRP12/NLRP3 (show NLRP3 Antibodies)-dependent activation of caspase-1 (show CASP1 Antibodies) is likely to be a key event in mediating systemic production of IL-1beta (show IL1B Antibodies) and hypersensitivity to secondary bacterial infection during malaria.
The genetics, expression and roles of NLRP12 in inflammatory signaling, host defense, and carcinogenes (show GUSB Antibodies)is are reviewed. Review.
This study suggested that NLRP12 mutations might account for a small fraction of common variable immunodeficiency patients with severe auto-inflammatory complications.
the data demonstrate a previously unappreciated role for Nlrp12 in exacerbating the pathogenesis of influenza A virus infection through the regulation of CXCL1 (show CXCL1 Antibodies)-mediated neutrophilic responses.
The results demonstrate that C57BL/6J mice have a functional defect in NLRP12, impaired CXCL1 (show CXCL1 Antibodies) production, and that macrophages require NLRP12 expression for effective recruitment of neutrophils to inflammatory sites.
Data show that TLR4 (show TLR4 Antibodies)-mediated up-regulation of Blimp-1 (show PRDM1 Antibodies) led to the down-regulation of NLRP12 expression in dextran sulfate sodium (DSS (show PMP22 Antibodies))-induced colitis.
this study shows that NLRP12 is essential for survival after radiation and thermal combined injury by regulating myelopoiesis and immune reconstitution
our findings suggest that NLRP12 plays an important role in negatively regulating the early inflammatory responses against B. abortus.
this study reveals a feed-forward loop in which NLRP12 promotes specific commensals that can reverse gut (show GUSB Antibodies) inflammation, while cytokine blockade during NLRP12 deficiency can reverse dysbiosis
Ambient fine particulate matter-induced myocarditis is mediated by EGFR (show EGFR Antibodies)/Akt (show AKT1 Antibodies) signaling and overexpression of NLRP3 (show NLRP3 Antibodies) and NLRP12.
Nlrp12 deficiency caused increased neutrophil migration towards the chemokine (show CCL1 Antibodies) CXCL1 (show CXCL1 Antibodies) and the neutrophil parasite Leishmania major, revealing NLRP12 as a negative regulator of directed neutrophil migration under these conditions.
modulation of NLRP12 levels controls alternative NF-kappaB (show NFKB1 Antibodies) signaling in OC precursors, altering bone homeostasis and osteolytic responses
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.
NACHT, leucine rich repeat and PYD containing 12
, NLR family, pyrin domain containing 12
, PYRIN-containing APAF1-like protein 7
, NACHT, LRR and PYD domains-containing protein 12
, NLR family, pyrin domain containing 12, isoform 2
, monarch 1
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12
, regulated by nitric oxide
, NACHT, LRR and PYD containing protein 12