NLRP12 antibody

Catalog No. ABIN3032016

The Rabbit Polyclonal anti-NLRP12 antibody (ABIN3032016) specifically detects NLRP12 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for NLRP12 antibody (ABIN3032016)

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NLRP12 Antibody

Purpose: Anti-NLRP12 Antibody

Purification: Antigen affinity

Immunogen: This anti-NLRP12 antibody was produced from rabbits immunized with human NLRP12 recombinant protein.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the anti-NLRP12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the anti-NLRP12 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for NLRP12

Target: NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))

Alternative Name: NLRP12

Background: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes.

UniProt: P59046

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome