Browse our phosphofructokinase, Muscle Proteins (PFKM)

Full name:: phosphofructokinase, Muscle Proteins (PFKM)

On www.antibodies-online.com are 15 phosphofructokinase, Muscle (PFKM) Proteins from 10 different suppliers available. Additionally we are shipping phosphofructokinase, Muscle Antibodies (98) and phosphofructokinase, Muscle Kits (38) and many more products for this protein. A total of 161 phosphofructokinase, Muscle products are currently listed.

Synonyms:: AI131669, GSD7, M-PFK, pfk, PFK-1, Pfk-4, PFK-A, Pfk-M, PFK1, Pfk4, Pfka, pfkm, Pfkx, zgc:92344

list all proteins	Gene Name	GeneID	UniProt
	PFKM	5213	P08237
	PFKM	18642	P47857
	PFKM	65152	P47858
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phosphofructokinase, Muscle Proteins (PFKM) by Origin

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Human phosphofructokinase, Muscle (PFKM) interaction partners

KLK6 (show KLK1 Proteins) may be the key protease involved in the proteolytic modification of PFK-M.
Data indicate that 6-phosphofructo-2-kinase (show PFKFB3 Proteins)/fructose-2,6-biphosphatase3 (PFKFB3 (show PFKFB3 Proteins)) and phosphofructokinase (PFK1) expression allows discrimination between induced pluripotent stem cells (iPS (show SLC27A4 Proteins)) and cancer stem cells (CSCs).
characterize three PFK1 mutations and show they have distinct effects on allosteric regulation of PFKP (show PFKP Proteins) activity and lactate production.
Gene-based analysis identified an association between breast cancer and the phosphofructokinase-muscle (PFKM) gene on chromosome 12q13.11 that met the genome-wide gene-based threshold of 2.5 x 10(-6).
insulin (show INS Proteins)/phosphofructokinase (PFKM), overlaps with an expression quantitative trait loci
Asp (show ASIP Proteins)(543)Ala, a naturally occurring Tarui disease-causing mutation in the activating binding site, causes an increased efficacy of ATP at the inhibitory allosteric binding site.
Molecular genetic findings demonstrated the absence of specific genotype-phenotype correlations in PFKM gene mutations.
eukaryotic Pfk did not evolve from prokaryotic ancestors, reciprocal linkage of functionally opposed allosteric binding sites must have developed independently in prokaryotic and eukaryotic Pfk (convergent evolution).
Posttranslational modification of PFK1 enzyme might be the pivotal factor of deregulated glycolytic flux in tumors
Data indicate that substitution of residue at the citrate-binding site (D591V) of PFK-M resulted in the complete loss of activity.

Mouse (Murine) phosphofructokinase, Muscle (PFKM) interaction partners

insulin (show INS Proteins), the most known regulator of glucose consumption, specifically regulates the expression of PFKL (show PFKL Proteins) and PFKM, which impact the regulation of glycolysis in the cell.
This study demonstrated that the reveal PFK-1 as an important regulator of neurogenesis.
These results reveal a novel role of NRX in the regulation of PFK1 activity and in the balance between glycolysis and the pentose phosphate pathway.
Posttranslational modification of PFK1 enzyme might be the pivotal factor of deregulated glycolytic flux in tumors.
HK1S is tethered in the principal piece region by PFKMS, which in turn is bound tightly to GSTM5 (show GSTM5 Proteins) in the fibrous sheath of sperm.
Recombinant expression of caveolin-3 (show CAV3 Proteins) affects subcellular localization of PFK-M, by targeting PFK-M to plasma membrane and by trans-locating PFK-M to caveolae-enriched membrane domains. Strictly dependent on the concentration of extracellular glucose.
Identification of novel PFK-M transcripts in the testis and embryo.
Sequence analysis of Pfkm gene introns and exons was performed.
The results suggest the importance of phosphofructokinase-M for insulin (show INS Proteins) secretion, although glucokinase (show GCK Proteins) is the overall rate-limiting glucose sensor.
Thr-201 phosphorylation of Bad by JNK1 is required for PFK-1 activation

Horse (Equine) phosphofructokinase, Muscle (PFKM) interaction partners

The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.

Rabbit phosphofructokinase, Muscle (PFKM) interaction partners

Posttranslational modification of PFK1 enzyme might be the pivotal factor of deregulated glycolytic flux in tumors.

phosphofructokinase, Muscle (PFKM) Protein Profile

Protein Summary

Three phosphofructokinase isozymes exist in humans muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with phosphofructokinase, Muscle (PFKM)

phosphofructokinase, muscle (PFKM)
phosphofructokinase, muscle (Pfkm)
phosphofructokinase, muscle a (pfkma)
phosphofructokinase, muscle S homeolog (pfkm.S)

AI131669 protein
GSD7 protein
M-PFK protein
pfk protein
PFK-1 protein
Pfk-4 protein
PFK-A protein
Pfk-M protein
PFK1 protein
Pfk4 protein
Pfka protein
pfkm protein
Pfkx protein
zgc:92344 protein

Protein level used designations for PFKM

6-phosphofructo-1-kinase , 6-phosphofructokinase, muscle type , PFK-A , phosphofructo-1-kinase isozyme A , phosphofructokinase 1 , phosphofructokinase, polypeptide X , phosphofructokinase-M , phosphohexokinase , phosphofructokinase 4 , phosphofructokinase-1 A isozyme , phosphofructokinase-M (connecting peptide) , phosphofructokinase-A , 6-phosphofructokinase muscle type , muscle type phosphofructokinase , muscle phosphofructokinase , muscle-type phosphofructokinase , ATP-dependent 6-phosphofructokinase, muscle type , phosphofructokinase, muscle S homeolog

GENE ID	SPECIES
5213	Homo sapiens
18642	Mus musculus
65152	Rattus norvegicus
374064	Gallus gallus
403849	Canis lupus familiaris
451863	Pan troglodytes
506544	Bos taurus
733601	Sus scrofa
100034116	Equus caballus
100172585	Pongo abelii
100345647	Oryctolagus cuniculus
100733625	Cavia porcellus
447836	Danio rerio
446756	Xenopus laevis

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