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anti-Rat (Rattus) NUDT16 Antibodies:
anti-Human NUDT16 Antibodies:
anti-Mouse (Murine) NUDT16 Antibodies:
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data suggest the existence in T-ALL of a disrupted RNA decapping pathway, mediated by the DNA methylation (show HELLS Antibodies)-associated loss of NUDT16, which contributes to the natural history of the disease by stabilizing transforming factors, such as is the case of the leukemogenic protein C-MYC (show MYC Antibodies)
This study details structural and regulatory mechanisms explaining how substrates are selected for hydrolysis by human NUDT16.
The RNA decapping enzyme (show DCP1A Antibodies) NUDT16 selectively degrades 5'-TOP mRNAs during Rift Valley fever virus infection and this decay is triggered in response to mTOR (show FRAP1 Antibodies) attenuation via the translational repressor 4EBP1 (show EIF4EBP1 Antibodies)/2 axis.
hNUDT16 can also actively cleave the mGDP cap from mRNAs in the presence of Mg(2 (show MUC7 Antibodies))(+) or Mn(2)(+).
Like Dcp2 (show DCP2 Antibodies), Nudt16 also regulates the stability of a subset of mRNAs including a member of the motin family of proteins involved in angiogenesis.
NUDT16 is a (deoxy)inosine diphosphatase that may function mainly in the nucleus to protect cells from deleterious effects of (d)ITP (show ITPA Antibodies).
X29/H29K may be the nuclear counterparts of the cytoplasmic decapping machinery, localized in specialized bodies involved in RNA decay
Recombinant NUDT16, a decapping enzyme (show DCP1A Antibodies), has been crystallized. NUDT16 plays a pivotal role in U8 snoRNA stability.
binding interaction between syndesmos (show NUDT16L1 Antibodies) and syn4 (show STX4 Antibodies)(cyto) was characterized as a low-affinity interaction (Kd = 62 muM) by surface plasmon resonance and nuclear magnetic resonance
Structures of X29 with GTP (show AK3 Antibodies) or m7GpppA show a different mode of ligand binding from that of other cap binding proteins and suggest a possible three- or four-metal Nudix reaction mechanism.
RNA-decapping enzyme that binds specifically to U8 snoRNA. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and m227G caps from U8 snoRNA. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species (in vitro) (By similarity).
U8 snoRNA-decapping enzyme
, IDP phosphatase
, U8 snoRNA-binding protein H29K
, inosine diphosphate phosphatase
, m7GpppN-mRNA hydrolase
, nucleoside diphosphate-linked moiety X motif 16
, nudix motif 16
, nudix-type motif 16
, U8 snoRNA-binding protein X29