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Studies indicate that the autoimmune phenotype in DEF6 and SWAP-70 knock-out (DKO) mice is characterized by the accumulation of B cell subset that expresses high levels of CD11c and T-bet (ABCs).
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findings show characteristic changes in the lipidome of CD11c+ immune cells upon their activation, and reveal an important role of SWAP-70 in the selective generation and localization of ceramides
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DEF6 and SWAP70 are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology
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SWAP-70 is not a typical oncogene, but is required for spontaneous transformation of mouse embryo fibroblasts.
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These findings reveal an important role of SWAP-70 in the dynamic spatiotemporal regulation of F-actin networks.
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Cells expressing the mutant SWAP-70 exhibited faster growth than the parental or wild-type SWAP-70-expressing cells underscoring its role in neoplastic transformation.
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SWAP-70 is not required for podosome formation and F-actin turnover in dendritic cells.
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SWAP-70 deficiency reveals two pathways that contribute to spontaneous maturation of DCs.
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SWAP-70 controls IgE production through regulation of the antagonistic STAT6 and BCL6 occupancy of the germline IgE promoter
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A novel function of the F-actin binding and regulatory protein SWAP-70 in osteoclast biology, is reported.
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regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure.
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SWAP-70 regulates erythropoiesis by controlling alpha4 integrin.
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in a dose-dependent manner, SWAP-70 controls IRF-4 protein expression and thereby regulates the initiation of plasma cell differentiation
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SWAP-70-374 can activate some signaling pathways, including the ERK1/2 pathway, to transform MEFs
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These data demonstrate SWAP-70 as a novel regulator of S1P signaling necessary for dendritic cell motility and endocytosis.
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regulator of the cell adhesion and B-cell differentiation
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In mast cells SWAP-70 plays a role both in establishing the initial competence to degranulate and to develop into mature mast cells.
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SWAP-70 is an important regulator of specific effector pathways in c-kit signaling, including mast cell activation, migration, and cell adhesion
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These data identify SWAP-70 as a transient component of early macropinosomes.
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SWAP-70 deficiency uncouples germinal center formation from T-dependent antibody and long-lived plasma cell production and causes extrafollicular generation of high-affinity plasma cells, but does not adequately support the memory response.