Stathmin 1 Protein (STMN1) (AA 2-149) (His tag)

Catalog No. ABIN1097590

This Recombinant Stathmin 1 protein is expressed in Escherichia coli (E. coli).

Quick Overview for Stathmin 1 Protein (STMN1) (AA 2-149) (His tag) (ABIN1097590)

Target: Stathmin 1 (STMN1)

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 2-149

Purification tag / Conjugate: This Stathmin 1 protein is labelled with His tag.

Purpose: Recombinant Human Stathmin/STMN1 (C-6His)

Sequence: ASSDIQVKEL EKRASGQAFE LILSPRSKES VPEFPLSPPK KKDLSLEEIQ KKLEAAEERR KSHEAEVLKQ LAEKREHEKE VLQKAIEENN NFSKMAEEKL THKMEANKEN REAQMAAKLE RLREKDKHIE EVRKNKESKD PADETEADLE HHHHHH

Characteristics: Recombinant Human Stathmin/STMN1 is produced by our E. coli expression system. The target protein is expressed with sequence (Ala2-Asp149) of Human Stathmin.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: Stathmin 1 (STMN1)

Alternative Name: stathmin

Background: Stathmin (STMN1) is a ubiquitous cytosolic phosphoprotein which belongs to the Stathmin family. STMN1 is expressed in many tissues, with the highest expression in the brain, spinal cord, and cerebellum. It can also be expressed in the colon, ovary, placenta, uterus, and trachea. STMN1 participates in the regulation of the microtubule filament structure by destabilizing microtubules. STMN1 promotes the disassembly of microtubules and prevents assembly. STMN1 is involved in the control of the learned and innate fear. STMN1 is an intracellular relay integrating regulatory signals of the cellular environment and as an Oncoprotein in regulation of the cell cycle. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Mutation in STMN1 effects cell homeostasis that may lead to tumorigenicity.
Alternative Names: Stathmin, Leukemia-Associated Phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17, STMN1, C1orf215, LAP18, OP18

Molecular Weight: 18.37 kDa

UniProt: P16949

Pathways: MAPK Signaling, Microtubule Dynamics