NEIL2 Protein (AA 1-332) (His tag)
Quick Overview for NEIL2 Protein (AA 1-332) (His tag) (ABIN1098272)
Target
See all NEIL2 ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-332
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Purification tag / Conjugate
- This NEIL2 protein is labelled with His tag.
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Sequence
- MGSSHHHHHH SSGLVPRGSH MGSHMPEGPL VRKFHHLVSP FVGQQVVKTG GSSKKLQPAS LQSLWLQDTQ VHGKKLFLRF DLDEEMGPPG SSPTPEPPQK EVQKEGAADP KQVGEPSGQK TLDGSSRSAE LVPQGEDDSE YLERDAPAGD AGRWLRVSFG LFGSVWVNDF SRAKKANKRG DWRDPSPRLV LHFGGGGFLA FYNCQLSWSS SPVVTPTCDI LSEKFHRGQA LEALGQAQPV CYTLLDQRYF SGLGNIIKNE ALYRAGIHPL SLGSVLSASR REVLVDHVVE FSTAWLQGKF QGRPQHTQVY QKEQCPAGHQ VMKEAFGPED GLQRLTWWCP QCQPQLSEEP EQCQFS
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Purification
- > 85% by SDS-PAGE
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Endonuclease 8-like 2 (NEIL2) (AA 1-332) protein (GST tag)
NEIL2 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Endonuclease 8-like 2 (NEIL2) (AA 1-332) protein (His-IF2DI Tag)NEIL2 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. ELISA, WB
Endonuclease 8-like 2 (NEIL2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)NEIL2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Endonuclease 8-like 2 (NEIL2) (Transcript Variant 2) protein (Myc-DYKDDDDK Tag)NEIL2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.5 mg/mL
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Buffer
- 20 mM Tris-HCl buffer ( pH 8.0) containing 1 mM DTT, 10 % glycerol, 0.1M NaCl
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
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- NEIL2 (Endonuclease 8-like 2 (NEIL2))
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Alternative Name
- NEIL2
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Background
- Endonuclease 8-like 2, also known as NEIL2, belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction. It has negligible or undetectable activity with 8-oxoguanine, thymine glycol, 2-hydroxyadenine, hypoxanthine, and xanthine. Recombinant human NEIL2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
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Molecular Weight
- 39.4 kDa (356aa) confirmed by MALDI-TOF
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NCBI Accession
- NP_659480
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Pathways
- DNA Damage Repair
Target
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