Neuregulin 4 Protein (NRG4)
(3 references)Quick Overview for Neuregulin 4 Protein (NRG4) (ABIN1111850)
Target
See all Neuregulin 4 (NRG4) ProteinsProtein Type
Origin
Host
Application
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Purification
- >96%, as determined by SDS-PAGE and HPLC
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Endotoxin Level
- Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg)
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Biological Activity Comment
- The ED(50) was determined by the phosphorylation of ErbB2 and ErbB4 receptors in CHO cells, and was found to be <3ng/ml, corresponding to a specific activity of 3x 105 Units/mg.
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Neuregulin 4 (NRG4) (AA 1-115) protein (His tag)
custom-made NRG4 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Neuregulin 4 (NRG4) (AA 1-115) protein (His tag)custom-made NRG4 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Neuregulin 4 (NRG4) (AA 1-115) protein (GST tag)NRG4 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Neuregulin 4 (NRG4) (AA 1-61) protein (His tag)NRG4 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Neuregulin 4 (NRG4) (Active) proteinNRG4 Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
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Restrictions
- For Research Use only
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Storage
- -20 °C
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Storage Comment
- The lyophilized protein is stable for at least 2 years from date of receipt at -20° C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8° C for one month, or at -20° C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
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: "The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis." in: The American journal of pathology, Vol. 184, Issue 10, pp. 2768-78, (2016) (PubMed).
: "Pan-erbB inhibition potentiates BRAF inhibitors for melanoma treatment." in: Melanoma research, Vol. 24, Issue 3, pp. 207-18, (2014) (PubMed).
: "Expression of neuregulin 4 splice variants in normal human tissues and prostate cancer and their effects on cell motility." in: Endocrine-related cancer, Vol. 18, Issue 1, pp. 39-49, (2010) (PubMed).
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: "The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis." in: The American journal of pathology, Vol. 184, Issue 10, pp. 2768-78, (2016) (PubMed).
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- Neuregulin 4 (NRG4)
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Alternative Name
- Neuregulin-4
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Background
- Neuregulins (NDF, heregulin, GGF ARIA, or SMDF) are EGF- like growth and differentiation factors that signal through tyrosine kinase receptors of the ErbB family.The ErbB2 and ErbB4 receptors cooperate in transmission of neuregulin-1 signals in the heart, whereas ErbB2 and ErbB3 cooperate in neural crest cells.
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Molecular Weight
- Recombinant human Neuregulin-4 EGF domain is a disulfide-linked monomeric protein consisting of 62 amino acid residue subunits, and migrates as an approximately 7 kDa protein under non-reducing and reducing conditions in SDS-PAGE.
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NCBI Accession
- Q8WWG1
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Target
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