TSH receptor Protein

Catalog No. ABIN1330596

This Recombinant TSH receptor protein is expressed in Wheat germ and has been mentioned in 2+ publications.

Quick Overview for TSH receptor Protein (ABIN1330596)

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Protein Type: Recombinant

Origin: Human

Source: Wheat germ

Application: Affinity Purification (AP)

Product Details

Purpose: TSHR (Human) Recombinant Protein

Sequence: MRPADLLQLV LLLDLPRDLG GMGCSSPPCE CHQEEDFRVT CKDIQRIPSL PPSTQTLKLI ETHLRTIPSH AFSNLPNISR IYVSIDVTLQ QLESHSFYNL SKVTHIEIRN TRNLTYIDPD ALKELPLLKF LGIFNTGLKM FPDLTKVYST DIFFILEITD NPYMTSIPVN AFQGLCNETL TLKLYNNGFT SVQGYAFNGT KLDAVYLNKN KYLTVIDKDA FGGVYSGPSL LDVSQTSVTA LPSKGLEHLK ELIARNTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGILESLM CNESSMQSLR QRKSVNALNS PLHQEYEENL GDSIVGYKEK SKFQDTHNNA HYYVFFEEQE DEIIGFGQEL KNPQEETLQA FDSHYDYTIC GDSEDMVCTP KSDEFNPCED IMGYKFLRIV VWFVSLLALL GNVFVLLILL TSHYKLNVPR FLMCNLAFAD FCMGMYLLLI ASVDLYTHSE YYNHAIDWQT GPGCNTAGFF TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHACA IMVGGWVCCF LLALLPLVGI SSYAKVSICL PMDTETPLAL AYIVFVLTLN IVAFVIVCCC YVKIYITVRN PQYNPGDKDT KIAKRMAVLI FTDFICMAPI SFYALSAILN KPLITVSNSK ILLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGICK RQAQAYRGQR VPPKNSTDIQ VQKVTHEMRQ GLHNMEDVYE LIENSHLTPK KQGQISEEYM QTVL

Characteristics: Human TSHR full-length ORF (AAI56780.1) recombinant protein without tag.
This product is belong to Proteoliposome (PL).

Purification: in vitro wheat germ expression system with proprietary liposome technology

Application Details

Application Notes: Heating may cause protein aggregation. Please do not heat this product before electrophoresis.

Comment:

Preparation method: in vitro, wheat germ expression system with proprietary liposome technology

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 25 mM Tris-HCl of pH 8.0 containing 2 % glycerol.

Handling Advice: Aliquot to avoid repeated freezing and thawing.

Storage: -80 °C

Storage Comment: Best use within three months from the date of receipt of this protein.

References

Kumata, Nagata, Matsushita, Kuwamoto, Kato, Murakami, Fukata, Hayashi et al.: "Thyrotropin Receptor Antibody (TRAb)-IgM Levels Are Markedly Higher Than TRAb-IgG Levels in Graves' Disease Patients and Controls, and TRAb-IgM Production Is Related to Epstein-Barr Virus ..." in: Viral immunology, Vol. 29, Issue 8, pp. 459-463, (2016) (PubMed).

Nagata, Nakayama, Higaki, Ochi, Kanai, Matsushita, Kuwamoto, Kato, Murakami, Iwasaki, Nanba, Kimura, Hayashi: "Reactivation of persistent Epstein-Barr virus (EBV) causes secretion of thyrotropin receptor antibodies (TRAbs) in EBV-infected B lymphocytes with TRAbs on their surface." in: Autoimmunity, Vol. 48, Issue 5, pp. 328-35, (2015) (PubMed).

Target Details

Target: TSH receptor (TSHR) (Thyroid Stimulating Hormone Receptor (TSHR))

Alternative Name: TSHR

Background: Full Gene Name: thyroid stimulating hormone receptor
Synonyms: CHNG1,LGR3,MGC75129,hTSHR-I

Gene ID: 7253

Pathways: Thyroid Hormone Synthesis