FGF23 Protein (Fc Tag)
Quick Overview for FGF23 Protein (Fc Tag) (ABIN1344060)
Target
See all FGF23 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This FGF23 protein is labelled with Fc Tag.
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Purpose
- FGF-23 (human):Fc (human) (rec.)
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Cross-Reactivity
- Human
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Characteristics
- Human FGF-23 (aa25-251) are fused at the C-terminus to the Fc portion of human IgG1.
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Sterility
- Sterile filtered
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Endotoxin Level
- <0.1EU/μg purified protein (LAL test).
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Biological Activity Comment
- Activates ERK and FRS2alpha phosphorylation in Klotho expressing cells.
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Fibroblast Growth Factor 23 (FGF23) (AA 25-251) (Active) protein (His tag)
FGF23 Origin: Mouse Host: Escherichia coli (E. coli) > 90 % AcA, CC Active
Fibroblast Growth Factor 23 (FGF23) (AA 1-251) protein (GST tag)FGF23 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Fibroblast Growth Factor 23 (FGF23) (AA 25-251) protein (His tag)FGF23 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Fibroblast Growth Factor 23 (FGF23) (AA 25-251) protein (His-IF2DI Tag)FGF23 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Fibroblast Growth Factor 23 (FGF23) (AA 25-251), (full length) protein (His tag)FGF23 Origin: Rat Host: Yeast Recombinant > 90 % ELISA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- 0.2μm-filtered solution in PBS.
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Handling Advice
- After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- FGF23 (Fibroblast Growth Factor 23 (FGF23))
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Alternative Name
- FGF-23
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Background
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Fibroblast Growth Factor 23, Tumor-derived Hypophosphatemia-inducing Factor
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
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Molecular Weight
- ~60kDa (SDS-PAGE, full-length), FGF23 is cleaved between arg179 and ser 180 (~40kDa)
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UniProt
- Q9GZV9
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Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion
Target
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