Granulin Protein (GRN) (AA 1-602) (DYKDDDDK Tag)
Quick Overview for Granulin Protein (GRN) (AA 1-602) (DYKDDDDK Tag) (ABIN1344102)
Target
See all Granulin (GRN) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-602
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Purification tag / Conjugate
- This Granulin protein is labelled with DYKDDDDK Tag.
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Purpose
- Progranulin (rat) (rec.)
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Cross-Reactivity
- Rat
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Characteristics
- Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag.
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Sterility
- Sterile filtered
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Endotoxin Level
- <0.1EU/μg purified protein (LAL test).
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
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Handling Advice
- After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- Granulin (GRN)
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Alternative Name
- Progranulin
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Background
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Proepithelin, PEPI, PC Cell-derived Growth Factor
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is also a functional signaling receptor for progranulin as reported recently.
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Molecular Weight
- ~65kDa (SDS-PAGE)
Target
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