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Granulin Protein (GRN) (AA 1-602) (DYKDDDDK Tag)

This Recombinant Granulin protein is expressed in HEK-293 Cells.
Catalog No. ABIN1344102

Quick Overview for Granulin Protein (GRN) (AA 1-602) (DYKDDDDK Tag) (ABIN1344102)

Target

See all Granulin (GRN) Proteins
Granulin (GRN)

Protein Type

Recombinant

Origin

  • 15
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Rat

Source

  • 9
  • 7
  • 7
  • 2
  • 1
HEK-293 Cells

Application

SDS-PAGE (SDS)

Purity

>95 % (SDS-PAGE)
  • Protein Characteristics

    AA 1-602

    Purification tag / Conjugate

    This Granulin protein is labelled with DYKDDDDK Tag.

    Purpose

    Progranulin (rat) (rec.)

    Cross-Reactivity

    Rat

    Characteristics

    Signal peptide and rat progranulin (aa 1-602) are fused at the C-terminus to a FLAG®-tag.

    Sterility

    Sterile filtered

    Endotoxin Level

    <0.1EU/μg purified protein (LAL test).
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  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Buffer

    Lyophilized from 0.2μm-filtered solution in PBS.

    Handling Advice

    After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

    Storage

    4 °C,-20 °C

    Storage Comment

    Short Term Storage: +4°C

    Long Term Storage: -20°C

    Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

    Expiry Date

    6 months
  • Target

    Granulin (GRN)

    Alternative Name

    Progranulin

    Background

    Proepithelin, PEPI, PC Cell-derived Growth Factor

    Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is also a functional signaling receptor for progranulin as reported recently.

    Molecular Weight

    ~65kDa (SDS-PAGE)
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