JAG1 Protein (AA 1-1067) (Fc Tag)
Quick Overview for JAG1 Protein (AA 1-1067) (Fc Tag) (ABIN1344183)
Target
See all JAG1 ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Protein Characteristics
- AA 1-1067
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Purification tag / Conjugate
- This JAG1 protein is labelled with Fc Tag.
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Purpose
- Jagged-1 (human):Fc (human) (rec.)
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Cross-Reactivity
- Human
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Characteristics
- Signal peptide and extracellular domain of human Jagged-1 (HJ1, CD339) (aa 1-1067) are fused at the C-terminus to the Fc portion of human IgG1.
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Sterility
- Sterile filtered
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Endotoxin Level
- <0.1EU/μg purified protein (LAL test).
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Biological Activity Comment
- Inhibits adipogenesis of mesenchymal stem cells (MSCs). Induces Hes-1 in 3T3L-1 cells.
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Jagged 1 (JAG1) (AA 37-119) protein (GST tag)
JAG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Jagged 1 (JAG1) (AA 531-620) protein (GST tag)JAG1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.5 mg/mL
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Buffer
- 0.2μm-filtered solution in PBS.
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Handling Advice
- After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
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Storage
- 4 °C,-20 °C
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Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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Expiry Date
- 6 months
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- JAG1 (Jagged 1 (JAG1))
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Alternative Name
- Jagged-1
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Background
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Protein Jagged-1, hJ1, CD339, JAG1
Jagged-1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. It is involved in cell-fate decisions during hematopoiesis. Is involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Defects in Jagged-1 are the cause of Alagille syndrome type 1 (ALGS1) and tetralogy of Fallot (TOF).
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Molecular Weight
- ~150kDa (SDS-PAGE)
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UniProt
- P78504
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Pathways
- Notch Signaling, Stem Cell Maintenance
Target
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